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KMID : 0043320150380030402
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Archives of Pharmacal Research
2015 Volume.38 No. 3 p.402 ~ p.407
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Potential use of glioblastoma tumorsphere: clinical credentialing
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Kang Seok-Gu
Cheong Jae-Ho
Huh Yong-Min
Kim Eui-Hyun
Kim Sun-Ho
Chang Jong-Hee
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Abstract
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A decade ago, cancer stem cells (CSCs) were introduced as target cells for an innovative cancer treatment. Particularly, there have been a lot of biological researches on glioblastoma (GBM) CSCs. However, as there is a comprehensive change in the concept of CSCs, it is required to review how the different CSCs for patients can be clinically used, or clinical credentialing, and summarize the possibilities of clinical credentialing. In this regard, this review aims to introduce the tumorsphere obtained from GBM specimen and summarize the clinical dilemma and clinically applicable areas.
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KEYWORD
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Cancer stem cell, Clinical credentialing, Glioblastoma, Intratumoral heterogeneity, Testing platform, Tumorsphere
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